Outcome and Impact

The NEURIPIDES project expects major improvement from selecting neural activation/ connectivity targets that track the effects of the most successful brain stimulation treatment developed so far for PD, DBS of the subthalamic nucleus (STN). We will pursue this strategy both in relation to motor and non-motor symptoms, particularly depression and anxiety. The outcome will be to establish neurofeedback protocols for the rational treatment of motor and non-motor symptoms that can be used as add-on to DBS but also independent of DBS. Important is that the majority of PD patients will not have implanted electrodes in the foreseeable future for a variety of reasons, highlighting the need for non-invasive neuromodulation options.